Scenes were shot in places including Princeton University, Van Sant Covered Bridge, Jersey City and Hyatt Regency, as well as in lanes, alleys, one church and during the time of a village feast. For the particular song sequences in the film, Menon wanted 'churches, water and halls' and convinced the producers to finance a trip to USA, and in the process, the team became the first South Indian film to shoot in the country. In May, the team moved to USA to film the song sequences for 'Ee Hridayam' and 'Kundanapu Bomma', choreographed by Flexy Stu. Scenes were shot in the lakes of Alappuzha during April 2009 for a month, with the houseboats doubling up as caravans.

Babu Antony as Joseph Thekekuttu in the film Jessie (cameo appearance).

VTV Ganesh in an appearance in 'Manasaa' (cameo appearance).

Sudheer Babu as Jerry Thekkekuttu (Jessie's brother).

Lakshmi Ramakrishnan as Teresa Thekkekuttu (Jessie's mother).

Devan as Joseph Thekkekuttu (Jessie's father).

Sanjay Swaroop as Raghava Rao Sivakumar (Karthik's father).

Krishnudu as Krishnudu (Karthik's friend).

Silambarasan as himself (cameo appearance).The film ends at a theater where they watch Jessie. They then get married at a Hindu temple and a church. She refused to marry anyone her parents set up because they rejected Karthik. He sees Jessie three years later in the U.S. He calls upon Silambarasan as the film's protagonist and Trisha as the female lead. He then comes up with a script for his first film, which happens to be his own love story. She is rejected by Karthik who cites his previous affair with Jessie whom he can not get over. Two years later, Karthik meets Nandini ( Sapan Saran), who falls in love with him. Later on, Karthik learns that Jessie got married and is settled abroad. An angry and hurt Jessie makes a final decision to break up with Karthik because of her father's strong disapproval of their love.

After a tense phone call from Jessie, Karthik goes back one night to check on her. Busy Karthik is unable to attend to her calls and messages Jessie is unable to reach him. Suddenly, Jessie is forced by her father to marry and seeks Karthik's help, who was in Goa for a film shooting. Karthik and Jessie continue to love each other without the knowledge of their parents. But at the wedding, she refuses to marry the groom, Roy Thomas ( Surya), displeasing everyone in her family.

Her parents learn about their affair with this fight and arrange a marriage for her. Now, Jerry finds that they like each other and in the fight that follows we come to know that Karthik is a part-time boxer where he beats up Jerry and his friends. In the train he kisses her for which she slaps him and later the two meet several times afterwards and Jessie begins to admit that she likes Karthik but wants to refrain from any problems because she knows her father won't accept a Hindu marrying their daughter. After coming to know from her that she is going back to Hyderabad alone, he decides to turn the friendship in to love in the train journey. Then Karthik tells her that they can be good friends. Karthik gets to know this from his sister and goes to Alappuzha, along with his friend Krishnudu ( Krishnudu), where he gets introduces to her family as his classmate. Later Jessie goes to Alappuzha, her grandparents' place. Karthik expresses his love one day to her, who is afraid of speaking to men around her strict father, and ends up angering Jessie. When Karthik meets Jessie for the first time, he falls in love with her. Jessie ( Samantha), their daughter, is 2 years older than Karthik. Karthik's family rents the ground floor of a two-storeyed house which belongs to a Kerala Christian family who are very conservative Syrian Catholic family from Alappuzha, Kerala, who live upstairs. Karthik ( Naga Chaitanya) is a mechanical engineering graduate but aspires to become a filmmaker.

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